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Panacur Suspensie 2.5%.
Overview
Panacur Suspensie 2.5%.
Item No.:
008
(0 Reviews)
Dewormer for non lactating sheep.
(Price excluding VAT)
€
116,47
€
126,95
Panacur Suspensie
1 Ltr.
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Description
Panacur Suspensie 2.5%.
DELIVERY FORM
: «
drench
» for oral administration.
Sheep
Roundworms
:
Gastrointestinal roundworms
(adults & immatures):
Ostertagia
spp,
Haemonchus
spp,
Trichostrongylus
spp,
Nematodirus
spp,
Cooperia
spp,
Chabertia
spp,
Oesophagostomum
spp,
Strongyloides
spp,
Trichuris
spp (variable efficacy).
Lungworms:
of
Dictyocaulus
filaria
.
Tapeworms
:
Moniezia
spp.
RECOMMENDED DOSE*
* Country-specific differences may apply:
read the product label
.
Sheep
:
1 mL product/5 kg
bw (equivalent to 5.0 mg of
fenbendazole
/kg).
Thoroughly shaking suspensions before use is crucial for efficacy
. If the active ingredient remains in the sediment, a few animals may get most of the active ingredient and will be overdosed, and the large majority will get almost only solvents and will be underdosed.
ACTIVE INGREDIENT(S):
fenbendazole
25 mg/mL (equivalent to 2.5%). This formulation contains also 0.4 mg/mL elemental
selenium
and 0.94 mg/mL elemental
cobalt
.
CHEMICAL CLASS
of the active ingredient(s):
benzimidazole
Withholding periods
(=withdrawal times) in days for
meat & milk
(country-specific differences may apply: read the product label)
Meat
: UK 15 days.
Milk for human consumption
: UK 7 days
WARNING !!!
:
Never use on humans, dogs and cats.
PANACUR
is the original brand for products containing
fenbendazole
introduced already in the 1970s by HOECHST (later acquired by INTERVET, now MERCK MSD ANIMAL HEALTH = MSD ANIMAL HEALTH).
All
benzimidazoles
are veteran
anthelmintics
.
Fenbendazole
has a
broad-spectrum
of activity against
roundworms
(gastrointestinal and pulmonary) &
tapeworms
, but is ineffective against
flukes
.
Fenbendazole
also
kills eggs
of
roundworms
(
ovicidal
activity). As all
benzimidazoles
,
fenbendazole
has
no efficacy
whatsoever against external parasites (
ticks
,
flies
,
lice
,
mites
, etc). Among the
benzimidazoles
fenbendazole
is quite comparable with
oxfendazole
in terms of efficacy and safety.
As all
benzimidazoles
(as well as other
anthelmintics
such as
levamisole
,
monepantel
, and
tetrahydropyrimidines
),
fenbendazole
administered as a
drench
has
no residual effect
, i.e. it kills the parasites shortly after administration, but does not significantly protect the animals against re-infestation by infective stages in their environment.
Fenbendazole
is abundantly used worldwide in numberless generic brands for livestock, horses and pets.
Drench
is the preferred
delivery form
for use on cattle, sheep and goats, but in many countries it is also available in the form of
feed additives
(mainly for pig & poultry) and other delivery forms for oral administration (boluses, tablets, pastes, etc). As most
benzimidazoles
it is not appropriate for intramuscular or subcutaneous
injection
due to its poor solubility in water, but intraruminal injection is very popular in Latin America.
Both for livestock and pets
fenbendazole
is often used in
combinations
that broaden the spectrum of activity or try to overcome potential
resistance
. Typical mixtures for livestock include a
flukicide
(e.g.
closantel
, etc.) and/or a
macrocyclic lactone
, and/or
levamisole
, although such mixtures are not approved everywhere. For dogs and cats it is often combined with a
taenicide
(e.g.
praziquantel
).
Unfortunately,
resistance
of several
gastrointestinal
roundworms
to all
benzimidazoles
(including
fenbendazole
) is already very high and very frequent worldwide in
sheep
and
goats
, slightly lower in
cattl
e, which has significantly reduced their usage in livestock. Nowadays more convenient
pour-ons
and
injectables
containing
macrocyclic lactones
(e.g.
abamectin
,
doramectin
,
eprinomectin
,
ivermectin
,
moxidectin
) are often preferred over
drenches
with benzimidazoles.
Macrocyclic lactones
also ensure several weeks protection against re-infestation by several worm species, in contrast with all
benzimidazoles
that lack any residual effect.
In
ruminants
, reducing the amount of
feed
slows down the exit flow of the rumen and prolongs the time during which the
active ingredient
remains there and is absorbed. Consequently it is advisable to reduce the access of animals to feed (especially to fresh pasture, not to water) 24 hours before administration. For the same reason, it is better to keep the animals away from food for about 6 hours after drenching. However sick or weak animals should not be kept away from food and fasting animals should have access to water. In
cattle
, a fiber-rich diet also increases the bioavailability of
fenbendazole
.
Fenbendazole
active ingredient
is a solid compound
poorly soluble in water
and in
drenches
it is formulated as a
suspension
(not as a solution or as an emulsion). A key unfavorable feature of all suspensions is that the suspended solid particles tend to fall down to the bottom of the container and sediment, very much like sand in water. This means that
suspensions must be thoroughly shaken before use
. How fast the suspension sediments and how easily shaking the container redistributes the suspension depends on the formulation quality. A good formulation sediments slowly and shaking will re-suspend it quickly. Bad formulations sediment quickly and shaking re-suspends them slowly.
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